https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45867 Tue 06 Dec 2022 10:38:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47756 Nes^-/-) mice. We found that the proliferation of Nes^-/- neural stem cells was not altered, but neurogenesis in the hippocampal dentate gyrus of Nes^-/- mice was increased. Surprisingly, the proneurogenic effect of nestin deficiency was mediated by its function in the astrocyte niche. Through its role in Notch signaling from astrocytes to neural stem cells, nestin negatively regulates neuronal differentiation and survival; however, its expression in neural stem cells is not required for normal neurogenesis. In behavioral studies, nestin deficiency in mice did not affect associative learning but was associated with impaired long-term memory.]]> Fri 27 Jan 2023 10:25:04 AEDT ]]>